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Early in the s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the s, the number of these gouty patients increased, and in the s, research on the pathogenesis of gout was performed on the basis of approximately 2, cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals.

Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese.

Purine Synthesis

My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout.

During the s, the number of these gouty patients increased, and in the s, research on the pathogenesis of gout was performed on the basis of approximately 2, cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.

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Purine And Pyrimidine Metabolism In Man Vi: Part A: Clinical And Molecular Biology

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Purine and Pyrimidine Metabolism in Man VI

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